Pathological features and clinical behavior of Lynch syndrome-associated ovarian cancer
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چکیده
منابع مشابه
Clinical and Pathological Features of Iraqi Patients with Prostate Cancer
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We are delighted to have the opportunity to respond to the letter by Gilks et al. (Gilks et al., 2017). They argue first that historical pathological entities do not map seamlessly to modern day diagnostic categories, which are not only based on expert review by specialist gynecological pathologists but are also increasingly supported by immunohistochemistry (IHC). Second, that the misclassific...
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PURPOSE A woman with early-onset endometrial cancer (EC) may represent the "sentinel" cancer event in a Lynch syndrome kindred. The aim of this study was to determine the incidence of Lynch syndrome in a series of young-onset EC, and to identify molecular, clinical, and pathologic features that may alert clinicians to the presence of this disorder. EXPERIMENTAL DESIGN Patients with EC, ages <...
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BACKGROUND Approximately 2% to 5% of endometrial cancers may be due to an inherited susceptibility. Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, an autosomal-dominant inherited cancer susceptibility syndrome caused by a germline mutation in one of the DNA mismatch repair genes, accounts for the majority of inherited cases. Lynch syndrome is associate...
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BACKGROUND Over the last twenty years, the efforts of the scientific community devoted to the comprehension and treatment of ovarian cancer have remained poorly remunerative, with the case-fatality ratio of this disease remaining disappointedly high. Limited knowledge of the basic principles regulating ovarian carcinogenesis and factors impacting the course of disease may significantly impair o...
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ژورنال
عنوان ژورنال: Gynecologic Oncology
سال: 2017
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2017.01.005